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strain atcc 6303  (ATCC)


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    Structured Review

    ATCC strain atcc 6303
    a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae <t>ATCC-6303.</t> Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .
    Strain Atcc 6303, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 580 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/strains+atcc+6303/Streptococcus+Pneumoniae/bio_rxiv__64898__2026__01__10__698720-123-27-28
    Average 96 stars, based on 580 article reviews
    strain atcc 6303 - by Bioz Stars, 2026-10
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    1) Product Images from "Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection"

    Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

    Journal: bioRxiv

    doi: 10.64898/2026.01.10.698720

    a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .
    Figure Legend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

    Techniques Used: Infection, Virus, Two Tailed Test

    Related Articles

    Activation Assay:

    Article Title: Resistance to Both Complement Activation and Phagocytosis in Type 3 Pneumococci Is Mediated by the Binding of Complement Regulatory Protein Factor H
    Article Snippet: .. In conclusion, our results indicate that the virulence of the type 3 pneumococcal strains ATCC 6303 and WU2 is strongly related to their ability to resist complement activation and complement-mediated phagocytosis. ..

    Binding Assay:

    Article Title: Resistance to Both Complement Activation and Phagocytosis in Type 3 Pneumococci Is Mediated by the Binding of Complement Regulatory Protein Factor H
    Article Snippet: In contrast, in both ATCC 6303 and WU2, factor H binding was EDTA resistant and therefore independent of C3b deposition on either cell wall or capsule. .. Thus, our data indicate that virulent type 3 pneumococci carry specific receptors or binding sites for factor H. Factor H binding was strongly decreased by the pretreatment of strains ATCC 6303 and WU2 with trypsin, indicating that the putative factor H receptors are proteinaceous. .. In addition, trypsin pretreatment strongly enhanced complement activation and complement-dependent phagocytosis by ATCC 6303 and WU2.



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    a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae <t>ATCC-6303.</t> Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .
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    Image Search Results


    a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

    Journal: bioRxiv

    Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

    doi: 10.64898/2026.01.10.698720

    Figure Lengend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

    Article Snippet: To assess whether our findings on the adaptation of pneumococcus to the IAV-primed lung extend beyond the D39L strain (serotype 2), we performed parallel experiments using the strain ATCC-6303, a serotype 3 isolate.

    Techniques: Infection, Virus, Two Tailed Test

    a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

    Journal: bioRxiv

    Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

    doi: 10.64898/2026.01.10.698720

    Figure Lengend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

    Article Snippet: Together, these data suggest that in the ATCC-6303 strain, carbon source availability exerts a dominant influence over adh induction, with hypoxia playing a more limited modulatory role compared to observed in strain D39L.

    Techniques: Infection, Virus, Two Tailed Test